Phytochemicals As a Potential Inhibitor of COVID-19: An In-Silico Perspective

The current research has centered on the use of pharmacological and binding affinity methods to test 36 compounds as bioactive constituents’ inhibitors for COVID-19. Six out phytoconstituents (rutin, quercetin, catechin gallate, rhamnetin, campesterol stigmasterol) have demonstrated outstanding molecular docking drug-like properties HIV Lopinavir Indinavir. Interestingly, lowest energies (LBE) inhibition constant (Ki) showed that these are able bind P-glycoprotein substrate 3CLpro Nsp15. rutin been found be an excellent potential inhibitor COVID-19 proteins because it best LBE score Ki value than those other compounds, its ability form strong H-bonds with proteins. come next compound stigmasterol campesterol. As a result, considered possible novel In order validate computational results, more in vitro vivo investigations required support findings this research.